NFL Picks Against the Spread for Week 6

• See our best against the spread bets for NFL Week 6
• NFL underdogs of 5.5 points or more are 19-5-1 ATS and 13-12 SU this season
• Keep reading to see our NFL expert picks against the spread for Sunday, October 13

It’s another week in the NFL, and underdogs continue to cover the spread at an impressive rate. Out of 26 games, underdogs of at least 5.5 points have covered the spread in 19 of those games. They also have 13 outright wins. In my NFL ATS picks for Week 6, I am targeting one underdog of 5.5 points or more.

NFL Week 6 Picks Against the Spread

Week 6 features some intriguing matchups. With my best bets, I will preview an important NFC matchup between the Lions and Cowboys, a divisional game between the Falcons vs Panthers, and Sunday Night Football between the Bengals and Giants. See below to find out how I am betting on each of these games.

Lions vs Cowboys Odds

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NFL Pick #1: Lions -3 (vs. Cowboys)

Detroit is 3-1 against the spread this season, and the Lions have been great ATS for a while now. Over the last four years, the Lions are 38-17 against the spread (69.1%) in the regular season. Jared Goff has also been extremely profitable as a road favorite. Goff is 13-3 against the spread in his last 16 road games and is 6-1 ATS as a road favorite. With this game being played in a dome, I like the Lions to cover again on Sunday.

Dallas has yet to win (and cover) a home game this season. They struggle to run the ball, so Dak Prescott must have a big game. Without much of a run game, Aidan Hutchinson and co. will have the opportunity to make an impact as the Cowboys will likely face a lot of third and longs.

On the other side of the ball, Dallas’s rushing defense has been abysmal and now they face Detroit’s offensive line, David Montgomery, and Jahmyr Gibbs. I believe the Lions will run away with this one on Sunday afternoon.

• Pick: Lions -3 (-115)

Falcons vs Panthers Odds

NFL Pick #2: Panthers +6 (vs. Falcons)

You always have to take a deep breath before betting on the Panthers, but I like them in this spot. The NFL odds have them listed as near-touchdown home underdogs to a divisional opponent.

The Falcons have not fared well on the road and have lost outright in their last two games in Carolina. They are also just 3-7 against the spread in their last ten road games. I am also expecting a bit of a letdown for Atlanta. Three of their last four games have been prime-time games, and their last two games have also been divisional opponents.

Red Rifle, Black Helmet 😮‍💨 pic.twitter.com/m4ppWT0IWW

— Carolina Panthers (@Panthers) October 9, 2024

Atlanta has looked good to start the season, but I have a hard time trusting them to lay six points on the road. Even though they lost to the Bears last week, the Panthers have looked better with Andy Dalton under center. Carolina can keep this game close at home.

• Pick: Panthers +6 (-110)

Bengals vs Giants Odds

NFL Pick #3: Giants +3.5 (vs. Bengals)

I wrap up my NFL Week 6 best bets with Sunday Night Football. The Bengals are a surprising 1-4, and the Giants are 2-3. The Bengals have covered the spread in two of their five games, while the Giants have covered in three of five.

Cincinnati’s offense has looked the part, especially over the last few weeks. They are averaging 35 points per game in their last three, but they have only won one of those games. The Bengals defense has not been able to stop anyone. While the Giants do not have an explosive offense, over the past few games they have improved. Even without Malik Nabers and Devin Singletary last week, the Giants found a way to win the game. They can run the ball, and Daniel Jones has made just enough plays to sustain their drives.

The Bengals are trending in the wrong direction, and the Giants are showing signs of life. I’ll take my chances with the home team that has a better defense, and I especially like getting over a field goal with New York. Give me the G-Men on Sunday Night Football.

• Pick: Giants +3.5 (-110)